The Morphologic Spectrum of Hibernoma

Morphologic spectrum of granulomatous lesions

• Vol 7 • December 2005 768 A key question for understanding chronic inflammatory and autoimmune diseases is where the disease actually begins. Wegener’s granulomatosis is a potentially life-threatening chronic inflammatory disease of as yet unknown etiology, characterized by granuloma formation, vasculitis, and an autoimmune response to “Wegener’s autoantigen“ proteinase 3, a 29 kD neutrophila...

Intrathoracic hibernoma.

loculated fat cells morphologically similar to the hibernating gland tissues found in animals was first recognized 95 years ago. It was subsequently termed “hibernoma.” In 1966, 38 cases had been recorded, 4 of which were intrathoracic. Thirty years later, approximately 100 cases had been reported, of which only 7 were intrathoracic. A recent review of the English literature reveals 13 intratho...

Hibernoma of cervical region

A 42 year old male presented with swelling in the right posterior cervical region for a period of 2 months. Palpation revealed a soft, non tender, mobile swelling measuring 2 x 1 cms. An elective excision biopsy was performed. Gross examination showed a yellow to pale brown soft mass. On microscopy, a well circumscribed tumour composed of two populations of cells(uni-vacuolated white adipocytes...

Hibernoma (granular cell lipoma).

Spectrum of morphologic changes of lymph nodes in HIV infection.

Cervical lymph nodes biopsies from 31 HIV positive patients (with or without AIDS) were studied by histologic methods and immunohistochemistry (StreptABC staining of paraffin sections) to identify cellular and extracellular matrix components. The results were the following: (1) the biopsies were included in the stages of follicular hyperplasia without fragmentation FH-FF (4 cases); follicular h...